Payloads and Linkers

Payloads: NJ Bio has a variety of highly potent warheads/payloads in stock for advancing its clients’ ADC programs. The following is a list of several classes of payloads in our toolbox for preparing ADCs or protein drug conjugates (PDCs):

• PBD dimer analogs
• Duocarmycin analogs
• Auristatin analogs
• Maytansine analogs

Linkers: Antibody-drug conjugates (ADCs) are comprised of an antibody to which typically a cytotoxic agent is attached through a linker. The type of linker chemistry used significantly affects the potency, selectivity, and pharmacokinetics of the resulting ADC. NJ Bio can offer a variety of linkers tailored for specific proteins and targets. These linkers will be selected based on the type of protein, antibody and desired release mechanism for drug molecules keeping long-term stability of the protein as one of the priorities. A selection of cleavable and non-cleavable linkers and spacer molecules is available.